Nov. 13th, 2006
This paper actually wins my heretofore unassigned award for Most Peculiar Stem Cell Paper of The Year, and the Kellogg Prize for best use of Pritt Stick in a scientific figure (See Fig 1, just after p39). Redeems itself by having funky videos of cells linked, not that I can see any evidence of the phenomenon the paper describes in them, as they are entirely unlabelled...
It's a shame that poor use of terminology makes this paper appear even more bizarre than it is: it sounds like it could possibly describe an interesting and potentially important phenomenon. Interestingly, no subsequent publications corroborate these findings.
Potted version for non-specialists here.
"Neosis is the newly defined mode of cell division that occurs only in senescent, polyploid
cells, and has not been observed in normal diploid cells. Neosis is a parasexual, somatic, reduction
division displayed by a subset of multinucleate and/or polyploid giant cells or MN/PG cells formed
during the spontaneous senescent phase of normal cells at the end of their MLS or genetic stress-induced
accelerated senescence phase in tumor cells. " Uh... Okaaaaay.
It's a shame that poor use of terminology makes this paper appear even more bizarre than it is: it sounds like it could possibly describe an interesting and potentially important phenomenon. Interestingly, no subsequent publications corroborate these findings.
Potted version for non-specialists here.
"Neosis is the newly defined mode of cell division that occurs only in senescent, polyploid
cells, and has not been observed in normal diploid cells. Neosis is a parasexual, somatic, reduction
division displayed by a subset of multinucleate and/or polyploid giant cells or MN/PG cells formed
during the spontaneous senescent phase of normal cells at the end of their MLS or genetic stress-induced
accelerated senescence phase in tumor cells. " Uh... Okaaaaay.
This paper actually wins my heretofore unassigned award for Most Peculiar Stem Cell Paper of The Year, and the Kellogg Prize for best use of Pritt Stick in a scientific figure (See Fig 1, just after p39). Redeems itself by having funky videos of cells linked, not that I can see any evidence of the phenomenon the paper describes in them, as they are entirely unlabelled...
It's a shame that poor use of terminology makes this paper appear even more bizarre than it is: it sounds like it could possibly describe an interesting and potentially important phenomenon. Interestingly, no subsequent publications corroborate these findings.
Potted version for non-specialists here.
"Neosis is the newly defined mode of cell division that occurs only in senescent, polyploid
cells, and has not been observed in normal diploid cells. Neosis is a parasexual, somatic, reduction
division displayed by a subset of multinucleate and/or polyploid giant cells or MN/PG cells formed
during the spontaneous senescent phase of normal cells at the end of their MLS or genetic stress-induced
accelerated senescence phase in tumor cells. " Uh... Okaaaaay.
It's a shame that poor use of terminology makes this paper appear even more bizarre than it is: it sounds like it could possibly describe an interesting and potentially important phenomenon. Interestingly, no subsequent publications corroborate these findings.
Potted version for non-specialists here.
"Neosis is the newly defined mode of cell division that occurs only in senescent, polyploid
cells, and has not been observed in normal diploid cells. Neosis is a parasexual, somatic, reduction
division displayed by a subset of multinucleate and/or polyploid giant cells or MN/PG cells formed
during the spontaneous senescent phase of normal cells at the end of their MLS or genetic stress-induced
accelerated senescence phase in tumor cells. " Uh... Okaaaaay.